BIOE Seminar: Cryopreservation: an enabling technology for regenerative medicine and biodiversity

Friday, April 8, 2022
9:00 a.m.-10:00 a.m.
A. James Clark Hall, Room 2121
Dr. Shawn He
shawnhe@umd.edu

John Bischof
Department of Mechanical Engineering
University of Minnesota

Cryopreservation: an enabling technology for regenerative medicine and biodiversity

This event will be offered in a virtual format. Login details will be sent to current BIOE faculty, affiliates, students, postdocs, and those who have previously asked to subscribe to our seminars listserv. If you do not currently receive our weekly seminars emails but you wish to attend this event, please email Alyssa Tomlinson (awolice@umd.edu).

Abstract: 

This talk will introduce a new Gen-4 NSF Engineering Research Center entitled Advanced Technologies for the Preservation of Biological Systems (ATP-Bio). This ERC focuses on cryopreservation of living biological systems to improve human and eco-system health. The talk will also introduce several new technologies which focus on rapid rewarming technologies to improve cryopreservation. In one important example, gold and iron oxide nanoparticles are used to transduce optical or radiofrequency electromagnetic fields to affect heating of biomaterials at multiple scales (1 µL droplets to L systems). This application of “nanowarming” allows both rapid and uniform rewarming of vitrified (i.e., cryopreserved) biomaterials back from the cryogenic state, thereby avoiding crystallization and cracking failures. This and other new techniques allow rewarming at predictable and controllable rates from 10’s to 10,000,000’s of °C/min, thereby addressing a key technology bottleneck for larger (e.g., tissues and organs) and smaller vitrified systems (e.g., embryos and oocytes). These new rates now allow improved cell, tissue, and organ cryopreservation, including the first robust drosophila and zebrafish embryo cryopreservation methods yielding live and reproducing young. In summary, this talk demonstrates the growing opportunities for cryopreservation in regenerative medicine and biodiversity.

About the speaker: 

Bischof works in the area of thermal bioengineering with a focus on biopreservation, thermal therapy, and nanomedicine. His awards include the ASME Van Mow Medal and Fellowships in societies including Cryobiology, JSPS, ASME, IAMBE and AIMBE. He has served as the President of the Society for Cryobiology and Chair of the Bioengineering Division of the ASME. Bischof obtained a B.S. in Bioengineering from U.C. Berkeley (UCB) in 1987, an M.S. from UCB and U.C. San Francisco in 1989, and a Ph.D. in Mechanical Engineering from UCB in 1992. After a Post-doctoral Fellowship at Harvard in the Center for Engineering in Medicine, he joined the faculty of the University of Minnesota in 1993. Bischof is now a Distinguished McKnight University Professor and Kuhrmeyer Chair in the Departments of Mechanical and Biomedical Engineering, the Medtronic-Bakken Endowed Chair and Director of the Institute for Engineering in Medicine at the University of Minnesota, and Director of the new NSF Engineering Research Center ATP-Bio.

Audience: Public 

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