Faculty Directory

White, Ian

White, Ian

Associate Chair and Director of Undergraduate Studies
Professor
Fischell Fellow
Fischell Department of Bioengineering
Brain and Behavior Institute
Robert E. Fischell Institute for Biomedical Devices
3112 A. James Clark Hall
Website(s):

EDUCATION

Ph.D., Stanford University, 2002

 

At the Amplified Molecular Sensors Lab, we aim to overcome the challenges that are preventing the realization of the next generation of biosensing and diagnostic systems. In particular, we emphasize the development and application of novel amplification strategies to add orders of magnitude improvement to chemical and biomolecular sensing, while at the same time improving the simplicity and usability of sensors and diagnostic systems.


At the Amplified Molecular Sensors Lab, we aim to overcome the challenges that are preventing the realization of the next generation of biosensing and diagnostic systems. In particular, we emphasize the development and application of novel amplification strategies to add orders of magnitude improvement to chemical and biomolecular sensing, while at the same time improving the simplicity and usability of sensors and diagnostic systems.

BIOE457: Biomedical Instrumentation

BIOE431: Fundamentals of Biosensing Techniques, Instrumentation, and Applications

  • Alessandra C. Zimmerman, Ian M. White, and Jason D. Kahn, "Nucleic acid-cleaving catalytic DNA for sensing and therapeutics, Talanta, in press, 2020.

  • Hieu T. Nguyen, Shweta Ganapati, David Watts, Imaly A. Nanayakkara, Philip DeShong, Ian M. White, A new trimodal phenotypic reporter of extended-spectrum beta-lactamase activity, ACS Infectious Disease, in press, 2019. DOI:10.1021/acsinfecdis.9b00138.

  • Imaly A. Nanayakkara and Ian M. White, Demonstration of a quantitative triplex LAMP assay with an improved probe-based readout for the detection of MRSA, Analyst, 144, 3878 - 3885, 2019. DOI:10.1039/C9AN00671K.

  • John P. Goertz, Kerry DeMella, Benjamin Thompson, Ian M. White, and Srinivasa Raghavan, Responsive capsules that enable hermetic encapsulation of contents and their thermally triggered burst-release, Materials Horizons, in press, 2019. DOI:10.1039/c9mh00309f.

  • Stephen M. Restaino and Ian M. White, A critical review of flexible and porous SERS sensors for analytical chemistry at the point-of-sample, Analytica Chimica Acta, 1060, 17-29, 2019, DOI:10.1016/j.aca.2018.11.057

  • John P. Goertz, Kenya Colvin, Andrew Lippe, John Daristotle, Peter Kofinas, and Ian M. White, Multi-Stage Chemical Heating for Instrument-Free Biosensing, ACS Applied Materials and Interfaces, 10, 33043–33048, 2018. DOI:10.1021/acsami.8b11611

  • John P. Goertz and Ian M. White, Phase-change partitions for thermal automation of multi-step reactions, Analytical Chemistry, 90, 3708–3713, 2018. DOI:10.1021/acs.analchem.7b05400.

  • Stephen M. Restaino and Ian M. White, Real-time multiplexed PCR using surface enhanced Raman spectroscopy in a thermoplastic chip, Lab on a Chip, 18, 832-839, 2018. DOI:10.1039/C7LC01227F.

  • John P. Goertz and Ian M. White, Peroxidyme-Amplified Radical Chain Reaction (PARCR): Nested Photochemical and Biochemical Positive Feedback, Angewandte Chemie, 56, 13411–13415, 2017. DOI:10.1002/anie.201706163.

  • Imaly A. Nanayakkara, Weidong Cao, and Ian M. White, Simplifying nucleic acid amplification from whole blood with direct PCR on chitosan microparticles, Analytical Chemistry, 89, 3773–3779, 2017. DOI:10.1021/acs.analchem.7b00274.

  • Adam G. Berger, Stephen M. Restaino, and Ian M. White, Vertical-flow paper SERS system for therapeutic drug monitoring of flucytosine in serum, Analytica Chimica Acta, 949C, 59-66, 2017. DOI:10.1016/j.aca.2016.10.035

  • Kunal R. Pandit, Imaly A. Nanayakkara, Weidong Cao, Srinivasa R. Raghavan, and Ian M. White, Capture and direct amplification of DNA on chitosan microparticles in a single PCR-optimal solution, Analytical Chemistry, 87, 11022-11029, 2015. DOI:10.1021/acs.analchem.5b03006

  • Kunal R. Pandit, Paul E. Rueger, Richard V. Calabrese, Srinivasa R. Raghavan, and Ian M. White, Assessment of surfactants for efficient droplet PCR in mineral oil using the pendant drop technique, Journal of Colloids and Surfaces B: Biointerfaces, 126, 489-495, 2015. DOI:10.1016/j.colsurfb.2015.01.001

  • Jeffrey M. Burke, Kunal Pandit, John P. Goertz, and Ian M. White, Fabrication of rigid microstructures with thiol-ene-based soft lithography for continuous-flow cell lysis, Biomicrofluidics, 8, 056503, 2014. DOI:10.1063/1.4897135.

  • Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Multiplex detection of DNA targets using polymerase chain reaction (PCR) and paper surface enhanced Raman spectroscopy (SERS) chromatography, Applied Spectroscopy, 68, 909-915, 2014. DOI:10.1366/14-07451.

  • Jeffrey M. Burke, Rebecca E. Zubajlo, Elisabeth Smela, and Ian M. White, High-throughput particle separation and concentration using spiral inertial filtration, Biomicrofluidics, 8, 024105 2014. DOI:10.1063/1.4870399.

  • Jordan F. Betz, Wei W. Yu, Yi Cheng, Ian M. White, and Gary W. Rubloff, Simple SERS substrates: powerful, portable, and full of potential, Physical Chemistry Chemical Physics, 16, 2224-2239, 2014. DOI:10.1039/C3CP53560F.

  • Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Inkjet-printed fluidic paper devices for chemical and biological analytics using surface enhanced Raman spectroscopy, Journal of Selected Topics in Quantum Electronics, 20, 7300510, 2014. DOI:10.1109/JSTQE.2013.2286076.

  • Soroush H. Yazdi, Kristen L. Giles, and Ian M. White, Multiplexed detection of DNA sequences using a competitive displacement assay in an microfluidic SERRS-based device, Analytical Chemistry, 85, 10605-10611, 2013. DOI:10.1021/ac402744z.

  • Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Highly sensitive and flexible inkjet printed SERS sensors on paper, Methods, 63, 219-224, 2013. DOI:10.1016/j.ymeth.2013.07.010.

  • Wei W. Yu and Ian M. White, Chromatographic separation and detection of target analytes from complex samples using inkjet printed SERS substrates, Analyst, 138, 3679-3686 2013. DOI:10.1039/C3AN00673E.

  • Katayoon Saadin, Jeffrey M. Burke, Neerav P. Patel, Rebecca E. Zubajlo, and Ian M. White, Enrichment of tumor-initiating breast cancer cells within a mammosphere-culture microdevice, Biomedical Microdevices, 15, 645-655, 2013. DOI:10.1007/s10544-013-9755-y.

  • Wei W. Yu and Ian M. White, Inkjet-Printed Paper-Based SERS Dipsticks and Swabs for Trace Chemical Detection, Analyst, 138, 1020-1025, 2013. DOI:10.1039/C2AN36116G. (outside front cover)

  • Soroush H. Yazdi and Ian M. White, Multiplexed detection of aquaculture fungicides using a pump-free optofluidic SERS microsystem, Analyst, 138, 100-103, 2013. DOI:10.1039/C2AN36232E.

  • Soroush H. Yazdi and Ian M. White, Multiplexed detection of aquaculture fungicides using a pump-free optofluidic SERS microsystem, Analyst, 138, 100-103, 2013. DOI:10.1039/C2AN36232E.

  • Soroush H. Yazdi and Ian M. White, An Optofluidic SERS Microsystem for Sensitive and Repeatable On-Site Detection of Chemical Contaminants, Analytical Chemistry, 84, 7992-7998, 2012. DOI:10.1021/ac301747b.

  • Katayoon Saadin and Ian M. White, Breast cancer stem cell enrichment and isolation by mammosphere culture and its potential diagnostic applications, Expert Reviews of Molecular Diagnostics, 13, 49-60, 2013. DOI:10.1586/erm.12.117.

  • Ian M. White, Soroush H. Yazdi, and Wei W. Yu, Optofluidic SERS: synergizing photonics and microfluidics for chemical and biological analysis, Microfluidics and Nanofluidics, 12, 205-216, 2012. DOI:10.1007/s10404-012-0962-2

  • Wei W. Yu and Ian M. White, A simple filter-based approach to surface enhanced Raman spectroscopy for trace chemical detection, Analyst, 137, 168-173, 2012. DOI:10.1039/C2AN15947C.

  • Soroush H. Yazdi and Ian M. White, A nanoporous optofluidic microsystem for highly sensitive and repeatable SERS detection, Biomicrofluidics, 6, 014105, 2012. DOI:10.1063/1.3677369. (selected for publication in the Virtual Journal of Nanoscale Science and Technology and the Virtual Journal of Biological Physics Research)

  • Xudong Fan and Ian M. White, Optofluidic microsystems for chemical and biological analysis, Nature Photonics, 5, 591-597, 2011. DOI:10.1038/nphoton.2011.206.

  • I-Jane Chen and Ian M. White, High-sensitivity electrochemical enzyme-linked assay on a microfluidic interdigitated microelectrode, Biosensors and Bioelectronics, 26, 4375-4381, 2011. DOI:10.1016/j.bios.2011.04.044.

  • Wei W. Yu and Ian M. White, Inkjet Printed Surface Enhanced Raman Spectroscopy Array on Cellulose Paper, Analytical Chemistry 82, 9626-9630, 2010. DOI:10.1021/ac102475k.

  • Jikun Liu, Ian M. White, and Don L. DeVoe, Nanoparticle-Functionalized Porous Polymer Monolith Detection Elements for Surface-Enhanced Raman Scattering, Analytical Chemistry, 83, 2119-2124, 2011. DOI:10.1021/ac102932d.

Brick by Brick: The Clark School Celebrates LGBTQ+ Engineers

At Maryland Engineering, we celebrate the array of experiences, stories, and contributions among our community of innovators.  

Professor Chris Jewell Accepts New Position in Fischell Institute

Chris Jewell has joined the Fischell Institute as the Robert E. Fischell Institute Professor of Translational Engineering.

A Ventilation Coach for Opioid Overdose Bystanders Takes Top Prize at Inaugural Capstone Design Expo

More than 500 Clark School Seniors Showcase Engineering Solutions to Real-World Problems

Jenna Mueller Receives NSF CAREER Award

The award will support Mueller’s research to develop affordable, accessible technologies for cervical dysplasia in low-income communities around the world.

Fischell Institute, Department of Commerce Host First Annual Maryland MedTech Summit

The event drew more than 160 people, including medical device innovators, investors, universities, the U.S. Food and Drug Administration, National Institute of Standards and Technology, National Institutes of Health, additional government agencies, and more, to celebrate and build on Maryland’s growing medtech industry.

Fischell Institute Spotlight: Ian White

Ian White is a Fischell Fellow and Professor and Director of Undergraduate Studies for the Fischell Department of Bioengineering.

Jewell Named Associate Editor of Regenerative Medicine

Bioengineering Professor named to Nature Portfolio Journal editorial board.

Combating Metastatic Cancer Through Blood Draw

University of Maryland bioengineers develop a new technique to efficiently capture, gently release, and effectively scale up circulating tumor cells, a leading culprit in cancer spread.

Jewell Named Controlled Release Society Fellow

BIOE Professor recognized for outstanding contributions to the field of delivery science and technology.

Maryland Engineering's Chris Jewell Appointed MPower Professor

Bioengineering professor one of eight UMD/UMB professors to receive UMD Strategic Partnership appointment.

Jewell Named BMES Fellow

BIOE Minta Martin Professor of Engineering Chris Jewell was named to the 2021 BMES Class of Fellows.

Everitt, Gaitan Granted 2020-2021 Fischell Fellowship

The department has named Fischell Fellows annually since 2003.

Secretary of State: 'Domestic Renewal' Needed Through Infrastructure Investments

Blinken emphasizes importance of spending at home to remain global leader in campus speech.

He Lab Taps Machine Learning to Improve Cell-Based Medicine

Technology could one day be used to improve stem cell-based therapies as well as treatment options for diabetes and infertility.

White Lab Reviews Point-of-Care Diagnostics to Combat Pandemic

Micaela Everitt is first author of a review paper on point-of-care diagnostic technologies during a pandemic.

Waging War on Metastatic Cancer

BIOE Professor Xiaoming He and his research team take a new approach to understand why cancers spread.

Jewell Named 2021 Miegunyah Distinguished Visiting Fellow at the University of Melbourne

BIOE professor will collaborate on vaccine technologies at Peter Doherty Institute for Infection & Immunity 

Better, Cheaper COVID-19 Tests

Compact, reusable system could quickly and cheaply test for multiple respiratory viruses.

Edit your faculty profile