Bentley, William E.
Director, Robert E. Fischell Institute for Biomedical Devices
Director, Maryland Technology Enterprise Institute
Robert E. Fischell Institute for Biomedical Devices
Chemical and Biomolecular Engineering
Brain and Behavior Institute
EDUCATION
Ph.D., University of Colorado at Boulder, 1989
BACKGROUND
William E. Bentley is the Robert E. Fischell Distinguished Professor of Engineering and was founding Chair of the Fischell Department of Bioengineering. He is currently Inaugural Director of the Robert E. Fischell Institute for Biomedical Devices and director of the Maryland Technology Enterprise Institute (Mtech). He is also appointed to the Department of Chemical and Biomolecular Engineering at the University of Maryland, College Park and the Institute for Bioscience and Biotechnology Research. At Maryland since 1989, Dr. Bentley has focused his research on the development of molecular tools that facilitate the expression of biologically active proteins, having authored over 350 related archival publications. Recent interests are on deciphering and manipulating signal transduction pathways, including those of bacterial communication networks, for altering cell phenotype. To enable discovery, his lab develops new strategies for opening ‘communication’ between devices and biological systems by the creation and facile assembly of biologically functional interfaces. These concepts are emerging within the fields of ‘biofabrication’ that exploits biological components and processes for assembly and 'bioelectronics" that interface electronics with biology. He has served on advisory committees for the NIH, NSF, DOD, DOE, FDA, USDA, and several state agencies. He has mentored more than 40 PhDs and 15 postdocs, many now in leadership roles within industry, federal agencies, and academia. He co-founded a protein manufacturing company, Chesapeake PERL, based on insect larvae as mini bioreactors. Dr. Bentley was recipient of the SIM’s Schering-Plough Young Investigator Award, the Charles Thom Award of the SIMB, the Marvin Johnson Award of the BIOT Division in the ACS, and the AIChE’s FPB Division Award. He is also a Fellow of the ACS, AAAS, and AIMBE and is an elected member of the American Academy of Microbiology.
HONORS AND AWARDS
For the complete list, please visit Professor Bentley's website.
- Distinguished University Professor (2016)
- Robert E. Fischell Distinguished Chair of Engineering (2016)
- Charles Thom Award, Society of Industrial Microbiology and Biotechnology (2013)
- Elected Fellow, American Chemical Society (ACS) (2013)
- Elected Member, Electorate Nominating Committee, American Association for the Advancement of Science (2013)
- Meeting Keynote, Upstream Processing, BIOT Division of American Chemical Society’s 245th National Meeting, New Orleans (2013)
- AIChE Food, Pharmaceutical and Bioengineering Division Award in Chemical Engineering (2012)
- University System of Maryland (USM) Regents’ Faculty Award for Research/Scholarship/Creative Activity (2011)
- Robert E. Fischell Distinguished Professor (former)
- Herbert Rabin Distinguished Professor (former)
- Fellow, American Academy of Microbiology (AAM) (2007)
- Fellow, American Association for the Advancement of Science (2001)
- Fellow, American Institute for Medical and Biological Engineering (2001)
- Maryland's Outstanding Young Engineer, Maryland Science Center (1998)
- Washington Academy of Sciences Allen C. Davis Medal (1998)
- Schering-Plough Young Investigator Award (1996)
- Dow Outstanding New Faculty Award from the American Society for Engineering Education (1995)
- Society of Industrial Microbiology Outstanding Achievement in Engineering Sciences Award
PROFESSIONAL MEMBERSHIPS
- American Academy of Microbiology
- American Association for the Advancement of Science
- American Chemical Society
- American Institute of Chemical Engineers
- American Institute for Medical and Biological Engineering
- Biomedical Engineering Society
A RECENT PRESS RELEASE FROM THE AMERICAN CHEMICAL SOCIETY: https://youtu.be/bDnAElgYrOA?t=1
Biomolecular and metabolic engineering; cell-cell communication; heterologous protein expression; device/bio interfaces.
- Metabolic and Biomolecular Engineering - Quorum Sensing and in vivo Genetic Manipulation
- Biofabrication Engineering of Biological Signaling (bBIOS)
- Bridging the communication gap between biology and electronics through the use of redox molecules
- Characterization of AI-2 uptake in E. coli quorum sensing circuitry
- Development of a generic strategy for the covalent assembly of proteins onto patterned surfaces, including sensor surfaces
For more information, please visit Professor Bentley's web site.
- For a complete list of publications, please visit Professor Bentley's web site
- Stephens, K., Pozo, M., Tsao, C.-Y., Hauk, P., and W.E. Bentley (2019) Bacterial co-culture with cell signaling translator and growth controller modules for autonomously regulated culture composition, Nature Communications, 10, 4129, DOI: 10.1038/s41467-019-12027-6.
- McKay, R., Ghodasra, M., Schardt, J., Quan, D.N., Pottash, A.E., Shang, W., Jay, S.M., Payne, G.F., Chang, M.W., March, J.C., and W.E. Bentley (2018) A Platform of Genetically Engineered Bacteria as Vehicles for Localized Delivery of Therapeutics: Toward Applications for Crohn's Disease, Bioengineering and Translational Medicine, 3(3): 209-221, DOI: 10.1002/btm2.10113.
- Tschirhart, T., Kim, E., McKay, R., Ueda, H., Wu, H.C., Pottash, A.E., Zargar, A., Negrete, A., Shiloach, J., Payne, G.F., and W.E. Bentley (2017) Electronic Control of Gene Expression and Cell Behaviour in Escherichia coli Through Redox Signaling, Nature Communications, 8:14030, DOI:10.1038/ncomms14030.
- Hwang, I.Y., Koh, E., Wong, A., March, J.C., Bentley, W.E., Lee, Y.S., and M.W. Chang (2017) Engineered Probiotic Escherichia coli Can Eliminate and Prevent Pseudomonas aeruginosa Gut Infection in Animal Models, Nature Communications, 8, 15028, DOI:10:1038/ncomms15028.
- Terrell J.L., Wu H.C., Tsao C.Y., Barber N.B., Servinsky M.D., Payne G.F., and Bentley W.E. (2015) Nano-guided cell networks as conveyors of molecular communication, Nature Communications, doi: 10.1038/ncomms9500.
- Payne, G.F., Kim, E., Cheng, Y., Wu, H-C., Ghodssi, R., Rubloff, G.W., Raghavan, S.R., Culver, J.N, and W.E. Bentley (2013) Accessing Biology’s Toolbox for the Mesoscale Biofabrication of Soft Matter, Soft Matter, doi:10.1039/c3sm50527h.
- Kim, E., Gordonov, T., Liu, Y., Bentley, W. E., and G. F. Payne (2013) Reverse engineering to suggest biologically relevant redox activities of phenolic materials, ACS Chemical Biology 8, 716-724.
- Liba, B. D., Kim, E., Martin, A. N., Liu, Y., Bentley, W. E., and G.F. Payne (2013) Biofabricated film with enzymatic and redox-capacitor functionalities to harvest and store electrons, Biofabrication 5, 015008.
- Wu, H. C., Tsao, C. Y., Quan, D. N., Cheng, Y., Servinsky, M. D., Carter, K. K., Jee, K. J., Terrell, J. L., Zargar, A., Rubloff, G. W., Payne, G. F., Valdes, J. J., and W.E. Bentley (2013) Autonomous bacterial localization and gene expression based on nearby cell receptor density, Molecular Systems Biology 9, 636.
- Bentley, W.E., and G.F. Payne (2013) Nature’s Other Self-Assemblers, Science, 341(6142): 136-137.
- Carter, K.K., Valdes, J.J., and W.E. Bentley (2012) Pathway Engineering via Quorum Sensing and sRNA Riboregulators – Interconnected Networks and Controllers, Metabolic Engineering, 14(3): 281-288.
- Terrell, J.L., Gordonov, T., Cheng, Y., Wu, H.C., Sampey, D., Luo, X., Tsao, C.Y., Ghodssi, R., Rubloff, G.W., Payne, G.F., and W.E. Bentley (2012) Integrated Biofabrication for Electro-Addressed In-Film Bioprocessing, Biotechnology Journal, 7(3):428-439.
- Cheng, Y., Tsao, C.-Y., Wu, H.-C., Luo, X.L., Terrell, J.L., Betz, J., Payne, G.F., Bentley, W.E., and G.W. Rubloff (2012) Electroaddressing Functionalized Polysaccharides as Model Biofilms for Interrogating Cell Signaling, Advanced Functional Materials, 22(3):519-528.
- Liu, Y., Terrell, J.L., Tsao, C.-Y., Wu, H.C., Jawaji, V., Kim, E., Cheng, Y., Wang, Y.F., Ulijn, R.V., Raghavan, S.R., Rubloff, G.W., Bentley, W.E., and G.F. Payne (2012) Biofabricating Multifunctional Soft Matter with Enzymes and Stimuli-Responsive Materials, Advanced Functional Materials, 22(14):3004-3012.
- Luo, X.L., Wu, H.C., Tsao, C.-Y., Cheng, Y., Betz, J., Payne, G.F., Rubloff, G.W., and W.E. Bentley (2012) Biofabrication of Stratified Biofilm Mimics for Observation and Control of Bacterial Signaling, Biomaterials, 33(20): 5136-5143.
- Gamby, S., Roy, V., Guo, M., Smith, J.A.I., Wang, J.X., Stewart, J.E., Wang, X., Bentley, W.E., and H.O. Sintim (2012) Altering the Communication Networks of Multispecies Microbial Systems Using a Diverse Toolbox of AI-2 Analogues, ACS Chemical Biology, 7(6):1023-1030.
- Kim, E., Liu, Y., Bentley, W.E., and G.F. Payne (2012) Redox Capacitor to Establish Bio-Device Redox-Connectivity, Advanced Functional Materials, 22(7):1409-1416.
- Gray, K. M., B. D. Liba, Y. Wang, Y. Cheng, G. W. Rubloff, W. E. Bentley, A. Montembault, I. Royaud, L. David, G. F. Payne (2012) Electrodeposition of a Biopolymeric Hydrogel: Potential for One-step Protein Electroaddressing. Biomacromolecules, 13(4), 1181-1189.
- Quan, D., W.E. Bentley (2012) Gene Network Homology in Prokaryotes Using a Similarity Search Approach: Queries of Quorum Sensing Signal Transduction. PLoS Computational Biology. E1002637.
- Tsao, C.-Y., Quan, D.Q. and W.E. Bentley (2012) Development of the Quorum Sensing Biotechnological Toolbox. Current Opinion in Chemical Engineering, DOI: 10.1016/j.coche.2012.09.008.
- Liu, Y., J. L. Terrell, C.-Y. Tsao, H.-C. Wu, V. Javvaji, E. Kim, Y. Cheng, Y. Wang, R. V. Ulijn, S. R. Raghavan, G. W. Rubloff, W. E. Bentley, G. F. Payne. (2012) Biofabricating Multi-functional Soft Matter with Enzymes and Stimuli-Responsive Materials. Advanced Functional Materials, doi: 10.1371/journal.pcbi.1002637.
- Tsao, C.Y., Hooshangi, S., Wu, H.C., Valdes, J.J., and W.E. Bentley (2010) Autonomous Induction of Recombinant Proteins by Minimally Rewiring Native Quorum Sensing Regulon of E. coli, Metabolic Engineering, 12(3):291-297.
- Carter, K.K., Valdes, J.J., and W.E. Bentley (2011) Pathway Engineering via Quorum Sensing and sRNA Riboregulators – Interconnected Networks and Controllers, Metabolic Engineering, (Epub, PMID22155614).
- Luo, X.L., Buckhout-White, S., Bentley, W.E., and G.W. Rubloff (2011) Biofabrication of Chitosan-Silver Composite SERS Substrates Enabling Quantification of Adenine by a Spectroscopic Shift, Biofabrication, 3(3):034108.
- Cheng, Y., Luo, X., Tsao, C.-Y., Wu, H.C., Betz, J., Payne, G.F., Bentley, W.E., and G.W. Rubloff (2011) Biocompatible multi-address 3D Cell Assembly in Microfluidic Devices Using Spatially Programmable Gel Formation, Lab on a Chip, 11(14):2316-2318.
- Kamaraju, K., Smith, J., Wang, J., Roy, V., Sintim, H.O., Bentley, W.E., and S. Sukharev (2011) Effects on Membrane Lateral Pressure Suggest Permeation Mechanisms for Bacterial Quorum Sensing Molecules, Biochemistry, 50(32):6983-93.
- Wang, Y., Liu, Y., Cheng, Y., Kim, E., Rubloff, G.W., Bentley, W.E., and G.F. Payne (2011) Coupling Electrodeposition with Layer-by-Layer Assembly to Address Proteins within Microfluidic Channels, Advanced Materials, 23(8):5817-5821
- Fernandes, R., Roy, V., Wu, H.C., and W.E. Bentley (2010) Engineered biological nanofactories trigger quorum sensing response in targeted bacteria, Nature Nanotechnology, 5(3)213-217.
- Fernandes R., Luo, X., Tsao, C.-Y., Payne, G.F., Ghodssi, R., Rubloff, G.W., and W.E. Bentley (2010) Biological Nanofactories Facilitate Spatially Selective Capture and Manipulation of Quorum-Sensing Bacteria in a BioMEMS Device, Lab on a Chip, 10(9):1128-1134.
- Roy, V., Fernandes, R., Tsao, C.Y., and W.E. Bentley (2010) Cross Species Quorum Quenching Using A Native AI-2 Processing Enzyme, ACS Chemical Biology, 5(2):223-232.
- Yang, X.H., Kim, E., Liu, T., Shi, X.W., Rubloff, G.W., Ghodssi, R., Bentley, W.E., and G.F. Payne (2010) In-film Bioprocessing and Immunoanalysis with Electroaddressable Stimuli-Responsive Polysaccharides, Advanced Functional Materials, 20(10):1645-1652.
- Liu, Y., Kim, E., Ghodssi, R., Rubloff, G.W., Culver, J.N., Bentley, W.E., and G.F. Payne (2010) Biofabrication to Build the Biology-Device Interface, Biofabrication, 2(2):220.
- Li, J., Attila, C., Wang, L., Wood, T.K., Valdes, J.J., and W.E. Bentley (2007) Quorum Sensing in E. coli is Signaled by AI-2/LsrR: Effects on sRNA and Biofilm Architecture, Journal of Bacteriology, 73:4100-4109.
- Fernandes, R., Tsao, C.Y., Hashimoto, Y., Wang, L., Wood, T.K., Payne, G.F., and W.E. Bentley (2007) Magnetic Nanofactories: Localized Synthesis and Delivery of Quorum-Sensing Signaling Molecule Autoinducer-2 to Bacterial Cell Surfaces, Metabolic Engineering, 9:228-239.
- Kim, E.J., Kramer, S.F., Hebert, C.G., Valdes, J.J., and W.E. Bentley (2007) Metabolic Engineering of the Baculovirus-Expression System via Inverse "Shotgun" Genomic Analysis & RNA Interference (dsRNA) Increases Product Yield and Cell Longevity, Biotechnology and Bioengineering, 98:645-654.
- March, J.C., and W.E. Bentley (2007) RNAi-based Tuning of Cell Cycling in Drosophila S2 cells- effects on Recombinant Protein Yield, Applied Microbiology and Biotechnology, 73: 1128-1135.
- Lewandowski, A.T., Small, D.A., Chen, T., Payne, G.F., and W.E. Bentley (2006) Tyrosine-based "activatable pro-tag": enzyme-catalyzed protein capture and release, Biotechnology and Bioengineering, 93:1207-1215.
- Chang, W., Small, D.A., Toghrol, F., and W.E. Bentley (2006) Global Transcriptome Analysis of Staphylococcus aureus Response to Hydrogen Peroxide, Journal of Bacteriology, 188:1648-1659.
- Gonzalez Barrios, A.F., Zuo R., Hashimoto, Y., Yang, L., Bentley W.E., and T.K. Wood (2006) Autoinducer 2 Controls Biofilm Formation in Escherichia coli Through a Novel Motility Quorum-sensing Regulator (MqsR, B3022), Journal of Bacteriology, 188:205-316.
- Li, J., Wang, L., Hashimoto, Y., Tsao, C-Y., Wood, T.K., Valdes, J.J., Zafiriou, E., and W.E. Bentley (2006) Stochastic Model of E. coli AI-2 Quorum Signal Circuit Reveals Alternative Synthesis Pathways, Nature Molecular Systems Biology.
- Wang, L., Hashimoto, Y., Tsao, C.-Y., Valdes, J.J., and W.E. Bentley (2005) cAMP and cAMP Receptor Protein (CRP) Influence Both Synthesis and Uptake of Extracellular Autoinducer-2 in Escherichia coli, Journal of Bacteriology, 187:2066-76.
- Yi, H., Wu, L.Q., Rubloff, G.W., Ghodssi, R., Payne, G.F., and Bentley, W.E., (2005) Signal-Directed Sequential Assembly of Biomolecules on Patterned Surfaces. Langmuir, 2:2104-2107.
- Bleckwenn, N. A., Golding, H., Bentley, W. E., Shiloach, J., (2005) Production of Recombinant Proteins by Vaccinia Virus in a Microcarrier Based Mammalian Cell Perfusion Bioreactor, Biotechnology and Bioengineering, 90:663-674.
- Chang, W., Small, D.A. Toghrol, F., and W.E. Bentley (2005) Microarray Analysis of Toxicogenomic Effects of Peracetic Acid on Pseudomonas aeruginosa, Environmental Science & Technology, 39:5893-5899.
- Chang, W., Small, D.A., Toghrol, F., and W.E. Bentley (2005) Microarray Analysis of Pseudomonas aeruginosa Reveals Induction of Pyocin Genes in Response to Hydrogen Peroxide, BMC Genomics, 6.115-129.
- Wang, L., Li, J., March, J.C., Valdes, J.J., and W.E. Bentley (2005), luxS-Dependent Gene Regulation in Escherichia coli K-12 Revealed by Genomic Expression Profiling, Journal of Bacteriology, 187:8350-8360.
- Yi, H., Wu, L.Q., Bentley, W.E., Ghodssi, R., Rubloff, G.W., Culver, J.N., Payne, G.F., (2005) Biofabrication with Chitosan, Biomacromolecules, 6:2881-2894.
Bentley and Narula Attend 10th Annual BioHealth Capital Region Forum
The 10th Annual BioHealth Capital Region Forum was held at the US Pharmacopeia (USP) in Rockville, Maryland.Robert E. Fischell Institute for Biomedical Devices invests $200K in the future of biomedical devices, cultivating up-and-coming investigators and immersing them in successful multidisciplinary teams
Designed to bolster young, postdoctoral researchers by pairing them with existing, proven research teams, the fellowship aims to propel the careers of awardees, enabling them to apply for additional grants or faculty positions in the future.Sally Wang Joins Princeton Bioengineering Institute - Innovators Distinguished Postdoctoral Fellowship Program
The fellowship fosters community and collaborative work within the Omenn-Darling Bioengineering Institute (ODBI) at Princeton University. Awarded fellows work with two or more Princeton faculty to establish an interdisciplinary research plan for bioengineering projects.Bill Bentley Receives Amgen Biochemical and Molecular Engineering Award
Supported by Amgen Inc., a leading biotechnology company, this prestigious award is given in memory of James E. Bailey to recognize research excellence and leadership in biochemical and molecular engineering.PocketPeds and UMD App Development Club Celebrate Upcoming App Launch
The PocketPeds app aims to decrease the number of accidental child overdoses on OTC medications by calculating individualized dosages for children based on their age and weightProfessor Chris Jewell Accepts New Position in Fischell Institute
Chris Jewell has joined the Fischell Institute as the Robert E. Fischell Institute Professor of Translational Engineering.Greg Payne Receives Provost’s Excellence Award for Professional Track Faculty
Award recipients receive a letter of recognition from the provost and $1,000.Fischell Institute Students Receive Awards at ChBE Department Showcase
The Chemical and Biomolecular Engineering Department Showcase was held on April 19, 2024.Fischell Institute Hosts Take Your Child to Work Day Event
The event included faculty and staff children participating in four family-friendly engineering activities.PocketPeds App wins 12th Annual M-CERSI America’s Got Regulatory Science Talent Competition
The app will calculate individualized dosages for over-the-counter (OTC) medications for children based on their age and weight.Fischell Institute, Department of Commerce Host First Annual Maryland MedTech Summit
The event drew more than 160 people, including medical device innovators, investors, universities, the U.S. Food and Drug Administration, National Institute of Standards and Technology, National Institutes of Health, additional government agencies, and more, to celebrate and build on Maryland’s growing medtech industry.Bill Bentley Awarded AIMBE's Professional Impact Award in Mentoring
Bentley was nominated for this award by AIMBE Fellow and Fischell Department of Bioengineering Chair (BIOE) John FisherFischell Institute Spotlight: Daniella Gatus
Gatus’s research in Takeo Miyake’s lab at Waseda University involves bacterial electronics and the genetic modulation of E. coli.Creating the “Internet of Life”
UMD researchers publish new findings in their research to connect biological and electronic systems.Kayla Chun Named a Recipient of the Clark Doctoral Fellows Mid-Career Award
Chun is a fifth-year bioengineering Ph.D. candidate in Fischell Institute Director Bill Bentley’s Biomolecular and Metabolic Engineering Lab.Fischell Institute's Black History Month Spotlight: Briahnah Streeter
Briahnah Streeter is a second-year bioengineering Ph.D. student in Fischell Institute Director Bill Bentley's Biomolecular and Metabolic Engineering Laboratory. She earned her bachelor's degree in engineering science with a minor in engineering management from Vanderbilt University in 2022.CelestRay Secures FDA Clearance for Implantable Medical Device with Help from Fischell Institute
The clearance, which paves the way for CelestRay to legally market its implant, also marks the first medical device aided to market by the Fischell Institute since its launch in 2019.Fischell Institute Spotlight: Kayla Chun
Chun worked in the biotech industry before deciding it was time to get back into the classroom to further their career.2023 Winners of the America's Got Regulatory Science Talent Competition Present at FDA
The competition aimed to foster student interest in regulatory science, the science of developing new tools, standards and approaches to assess the safety, efficacy, quality and performance of FDA‐regulated products.Fischell Institute Spotlight: Bill Bentley
William “Bill” Bentley has been the Director of the Robert E. Fischell Institute of Biomedical Devices since its launch in 2019.Maryland Engineers Awarded Grants to Address Humanity's Grand Challenges
Twelve projects led by or involving Maryland Engineering faculty have been awarded funding through the Grand Challenges Grants Program, the largest and most comprehensive program of its kind ever introduced at the University of Maryland.Jay Awarded $300K FDA Grant to Support Extracellular Vesicle Research
Jay is collaborating with Fischell Institute Director and BIOE professor William Bentley.A New Antimicrobial Cotton Textile with Cu ions in Nanofibers
New Research Published in NatureFischell Institute Fellow Spotlight: Ryan Sochol
Dr. Ryan Sochol is a Fischell Institute Fellow with a focus on 3D micro/nanoprinting-enabled strategiesFischell Foundry Spotlight: Quinn Burke
Fischell Institute staff engineer Quinn Burke (B.S.'20, M. Eng.‘22 bioengineering) provides support to the Fischell Foundry.The Future of Biohybrid Devices
Fischell Institute researchers awarded $1.5M NSF grant to bridge gap between electronics, biologyNCC-PDI Announces Pediatric Medical Device Competition Winners
Fischell Institute, Children's National Hospital co-lead consortium, annual pitch competition.UMD Bioengineers Awarded $1M Moore Foundation Grant to Advance Bioelectronic Technology
Researchers use redox to drive two-way communication between electronics and biological systems.